Form: EFFECT

Notice of Effectiveness

April 30, 2008

UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

Notice of Effectiveness

Effectiveness Date: April 30, 2008 5:30 P.M.
Form: S-1
CIK: 0001042418
Company Name: COMMONWEALTH BIOTECHNOLOGIES INC
File Number: 333-148942