UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13D/A

Under the Securities Exchange Act of 1934
(Amendment No. 8)*

HedgePath Pharmaceuticals, Inc.

(Name of Issuer)

Common Stock, $0.0001 par value

(Title of Class of Securities)

42278K 102

(CUSIP Number)

(Name, Address and Telephone Number of Person
Authorized to Receive Notices and Communications)

July 5, 2018

(Date of Event which Requires Filing of this Statement)

If the filing person has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of §§ 240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the following box. ¨

Note: Schedules filed in paper format shall include a signed original and five copies of the schedule, including all exhibits. See §240.13d-7 for other parties to whom copies are to be sent.

^* The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

This Amendment No. 8 to Schedule 13D (this “Amendment No. 8”) amends the Schedule 13D originally filed on July 7, 2014 (the “Original Schedule 13D”) by Mayne Pharma Ventures Pty Ltd, an Australian company ACN 168 896 357 (“Mayne Ventures”), Mayne Pharma International Pty Ltd, an Australian company ACN 007 870 984 (“Mayne International”), and Mayne Pharma Group Limited, an Australian company ACN 115 832 963 (“Mayne Group” and, together with Mayne Ventures and Mayne International, collectively, the “Reporting Persons”), as amended by (i) Amendment No. 1 to Schedule 13D filed on May 22, 2015 (“Amendment No. 1”), (ii) Amendment No. 2 to Schedule 13D filed on June 16, 2016 (“Amendment No. 2”), (iii) Amendment No. 3 to Schedule 13D filed on November 8, 2016 (“Amendment No. 3”), (iv) Amendment No. 4 to Schedule 13D filed on November 16, 2016 (“Amendment No. 4”), (v) Amendment No. 5 to Schedule 13D filed on November 28, 2016 (“Amendment No. 5”), (vi) Amendment No. 6 to Schedule 13D filed on December 2, 2016 (“Amendment No. 6”) and (vii) Amendment No. 7 to Schedule 13D filed on January 11, 2018 (“Amendment No.7 and the Original Schedule 13D, as so amended, the “Statement”) relating to the Common Stock, par value $0.0001 per share (“Common Stock”), of HedgePath Pharmaceuticals, Inc. (the “Issuer”). Items 3, 5 and 6 of the Statement are hereby amended to the extent hereinafter expressly set forth. Capitalized terms used herein but not defined shall have the meanings attributed to them in the Original Schedule 13D, Amendment No. 1, Amendment No. 2, Amendment No. 3, Amendment No. 4, Amendment No. 5, Amendment No. 6 or Amendment No. 7, as applicable.

The information contained in Item 3 of the Statement is hereby amended and supplemented by adding the following information:

“On July 5, 2018, at the second closing contemplated by the securities purchase agreement dated January 8, 2018 between Mayne Ventures and the Issuer (the “2018 Purchase Agreement”), Mayne Ventures acquired 2,318,841 shares of Series B Convertible Preferred Stock, par value $0.0001 per share (“Series B Convertible Preferred Stock”), of the Issuer, Series A Warrants to purchase 1,739,131 shares of Common Stock (the “July 2018 Series A Warrants”) and Series B Warrants to purchase 1,739,131 shares of Common Stock (the “July 2018 Series B Warrants”) directly from the Issuer in a private placement for an aggregate purchase price of US$1,600,000. The source of funds for this acquisition was working capital. Each share of Series B Convertible Preferred Stock (i) may be converted by Mayne Ventures at any time into three shares of Common Stock and (ii) is entitled to the number of votes equal to the number of shares of Common Stock into which each such share of Series B Convertible Preferred Stock is convertible. The July Series A Warrants have an initial exercise price of US$0.23 and may be exercised by Mayne Ventures at any time prior to their expiration on July 5, 2020. The July 2018 Series B Warrants have an initial exercise price of US$0.275 and may be exercised by Mayne Ventures at any time prior to their expiration on July 5, 2023.

The foregoing descriptions of the 2018 Purchase Agreement, the Series B Convertible Preferred Stock, the Series A Warrants and the Series B Warrants do not purport to be complete and are qualified in their entirety by reference to the complete text of the 2018 Purchase Agreement, the Certificate of Designation of Series B Convertible Preferred Stock (as corrected by the Certificate of Correction of Designation of Series B Convertible Preferred Stock), the Series A Warrants and the Series B Warrants, which have been incorporated by reference as exhibits hereto, and are hereby incorporated herein by reference.”

The information contained in Item 5 is hereby amended and restated in its entirety as follows:

“(a) and (b)

Mayne Ventures directly holds 198,106,132 shares of Common Stock. In addition, Mayne Ventures may be deemed to have “beneficial ownership” within the meaning of Rule 13d-3 under the U.S. Securities Exchange Act of 1934, as amended (the “Exchange Act”), (i) the remaining 23,504,236 shares of Common Stock issuable upon exercise of the 2016 Warrant, (ii) the 10,434,783 shares of Common Stock issuable upon conversion of the January 2018 Series B Convertible Preferred Stock, (iii) the 2,608,696 shares of Common Stock issuable upon exercise of the January 2018 Series A Warrants, (iv) the 2,608,696 shares of Common Stock issuable upon exercise of the January 2018 Series B Warrants, (v) the 6,956,523 shares of Common Stock issuable upon conversion of the July 2018 Series B Convertible Preferred Stock, (vi) the 1,739,131 shares of Common Stock issuable upon exercise of the July 2018 Series A Warrants, and (vii) the 1,739,131 shares of Common Stock issuable upon exercise of the July 2018 Series B Warrants. Accordingly, Mayne Ventures may be deemed to beneficially own an aggregate of 247,697,328 shares of Common Stock, representing 59.1% of the Issuer’s issued and outstanding Common Stock. This beneficial ownership percentage assumes that there would be 419,265,462 shares of Common Stock issued and outstanding, consisting of 369,674,266 shares of Common Stock reported as issued and outstanding as of May 1, 2018 in the Issuer’s most recent Quarterly Report on Form 10-Q filed on May 1, 2018, plus (i) the remaining 23,504,236 shares of Common Stock issuable upon exercise of the 2016 Warrant, (ii) the 10,434,783 shares of Common Stock issuable upon conversion of the January 2018 Series B Convertible Preferred Stock, (iii) the 2,608,696 shares of Common Stock issuable upon exercise of the January 2018 Series A Warrants, (iv) the 2,608,696 shares of Common Stock issuable upon exercise of the January 2018 Series B Warrants, (v) the 6,956,523 shares of Common Stock issuable upon conversion of the July 2018 Series B Convertible Preferred Stock, (vi) the 1,739,131 shares of Common Stock issuable upon exercise of the July 2018 Series A Warrants, and (vii) the 1,739,131 shares of Common Stock issuable upon exercise of the July 2018 Series B Warrants.

Mayne International holds 100% of the equity securities of Mayne Ventures. Mayne Group holds 100% of the equity securities of Mayne International. Accordingly, Mayne International and Mayne Group may be deemed indirect beneficial owners of the reported securities held by Mayne Ventures. Mayne Ventures, Mayne International and Mayne Group share the power to vote or to direct the vote and dispose or to direct the disposition of the 247,697,328 shares of Common Stock set forth above.

(c)       Except as set forth herein, none of the Reporting Persons has engaged in any transactions in the class of securities reported on that were effected during the past sixty days.

(d)       Not applicable.

(e)       Not applicable.”

The information contained in Item 6 of the Statement is hereby amended and supplemented by adding the following information:

“On July 5, 2018, at the second closing under the 2018 Purchase Agreement, Mayne Ventures acquired 2,318,841 shares of Series B Convertible Preferred Stock, the July 2018 Series A Warrants and the July 2018 Series B Warrants directly from the Issuer in a private placement for an aggregate purchase price of US$1,600,000.

The foregoing descriptions of the 2018 Purchase Agreement, the Series B Convertible Preferred Stock, the Series A Warrants and the Series B Warrants do not purport to be complete and are qualified in their entirety by reference to the complete text of the 2018 Purchase Agreement, the Certificate of Designation of Series B Convertible Preferred Stock (as corrected by the Certificate of Correction of Designation of Series B Convertible Preferred Stock), the Series A Warrants and the Series B Warrants, which have been incorporated by reference as exhibits hereto, and are hereby incorporated herein by reference.”

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

Date: July 6, 2018